期刊
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
卷 37, 期 1, 页码 113-118出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/01932691.2015.1030028
关键词
MCM-41; mesoporous silica nanoparticles; stability; tableting
资金
- Medical University of Sofia (Council of Medical Science) [34/2014]
Mesoporous silica nanoparticles have been widely investigated as drug delivery systems. The present study evaluated physical stability of indomethacin loaded mesoporous MCM-41 nanoparticles. The size, polydispersity index, zeta-potential, and drug loading degree of nanoparticles were determined immediately after their preparation and after 6 months storage at 25 degrees C in dry state. The results showed insignificant changes in these parameters, suggesting high stability of nanoparticles and loaded indomethacin. The nanoparticles were formulated in tablets by direct compression. The low friability indicated good resistance during handling and storage. The formulation of the nanoparticles into tablets decreased the initial release of indomethacin.
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