2 '-deoxyadenosine bearing hydrophobic carborane pharmacophore

Modification of 2'-deoxyadenosine at position 8 with para-carborane boron cluster is described. Incorporation of boron cluster into nucleic base has been accomplished using Sonogashira palladium-catalyzed cross-coupling reaction or alternatively, Huisgen click type reaction. These are the first examples of adenosine derivatives with hydrophobic carborane pharmacophore attached to purine base.