期刊
PAIN
卷 127, 期 1-2, 页码 63-72出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.pain.2006.08.001
关键词
placebo analgesia; irritable bowel syndrome; brain imaging
资金
- National Center for Complementary & Integrative Health [R01AT001424] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS053090, T32NS045551] Funding Source: NIH RePORTER
- NCCIH NIH HHS [R01 AT001424] Funding Source: Medline
- NINDS NIH HHS [R01 NS053090, 1-R01-NS053090-01, T32 NS045551, R01 NS053090-03] Funding Source: Medline
Previous experiments found that placebos produced small decreases in neural activity of pain-related areas of the brain, yet decreases were only statistically significant after termination of stimuli and in proximity to when subjects rated them. These changes could reflect report bias rather than analgesia. This functional magnetic resonance imaging (fMRI) study examined whether placebo analgesia is accompanied by reductions in neural activity in pain-related areas of the brain during the time of stimulation. Brain activity of irritable bowel syndrome patients was measured in response to rectal distension by a balloon barostat. Large reductions in pain and in brain activation within pain-related regions (thalamus, somatosensory cortices, insula, and anterior cingulate cortex) occurred during the placebo condition. Results indicate that decreases in activity were related to placebo suggestion and a second factor (habituation/attention/conditioning). Although many factors influence placebo analgesia, it is accompanied by reduction in pain processing within the brain in clinically relevant conditions. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
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