期刊
GENOME BIOLOGY
卷 8, 期 6, 页码 -出版社
BMC
DOI: 10.1186/gb-2007-8-6-r124
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资金
- NHGRI NIH HHS [R01 HG002602, R01 HG02602] Funding Source: Medline
- NIGMS NIH HHS [P20 GM076222] Funding Source: Medline
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002602] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM076222] Funding Source: NIH RePORTER
Whole-genome alignments are invaluable for comparative genomics. Before doing any comparative analysis on a region of interest, one must have confidence in that region's alignment. We provide a methodology to measure the accuracy of arbitrary regions of these alignments, and apply it to the UCSC Genome Browser's 17-vertebrate alignment. We identify 9.7% (21 Mbp) of the human chromosome 1 alignment as suspiciously aligned. We present independent evidence that many of these suspicious regions represent misalignments.
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