期刊
NEW JOURNAL OF CHEMISTRY
卷 31, 期 12, 页码 1996-2014出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b712012e
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资金
- NIGMS NIH HHS [R01 GM046502, R01 GM046502-05] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM046502] Funding Source: NIH RePORTER
The tripodal tris( 2-mercapto-1-R-imidazolyl) hydroborato ligand system, [Tm-R], and its selenium counterpart, [Tse(R)], provide useful platforms for investigating organometallic and bioinorganic aspects of the chemistry of zinc, cadmium and mercury in sulfur-rich and selenium-rich coordination environments. For example, the tridentate [Tm-R] ligand provides an [S-3] donor array that is of use for mimicking aspects of zinc enzymes and proteins that have sulfur-rich active sites, such as the Ada DNA repair protein. With respect to mercury, an interesting application of the [Tm-But] ligand is the synthesis of the mercury alkyl compounds [Tm-But] HgR ( R = Me, Et) that react with PhSH to yield [Tm-But] HgSPh and RH, a reaction that emulates mercury detoxification by the organomercurial lyase, MerB. In addition to the tridentate [Tm-R] and [Tse(R)] ligands, applications of the bidentate counterparts, [Bm(R)] and [Bse(R)] are also described.
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