期刊
LAB ON A CHIP
卷 7, 期 4, 页码 523-525出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b615328c
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资金
- EPSRC [EP/E036252/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [GR/S84347/01, EP/E036252/1] Funding Source: researchfish
This Technical Note presents the direct surface modification of a glass/PTFE hybrid microfluidic chip, via radio frequency glow discharge plasma polymerisation of tetraethlylene glycol dimethylether ( tetraglyme), to produce hydrophilic, non-fouling, PEO-like surfaces. We use several techniques including X-ray photoelectron spectroscopy (XPS), direct enzyme-linked immunosorbent assays (ELISA) and immunofluorescent imaging to investigate the channel coatings. Our results indicate the successful deposition of a PEO-like coating onto microchannel surfaces that has both solution and shelf stability (> 3 months) and is capable of preventing fibrinogen adsorption to the microchannel surfaces.
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