期刊
NEUROPHARMACOLOGY
卷 52, 期 1, 页码 215-227出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2006.06.022
关键词
long-term potentiation; amygdala; fear conditioning; memory; learning; plasticity
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [K05MH067048, F32MH077458, R01MH046516, R37MH038774, P50MH058911] Funding Source: NIH RePORTER
- NIMH NIH HHS [F32 MH077458, MH077458, P50 MH58911, R37 MH38774, K05 MH067048, R01 MH46516] Funding Source: Medline
Much of the research on long-term potentiation (LTP) is motivated by the question of whether changes in synaptic strength similar to LTP underlie learning and memory. Here we discuss findings from studies on fear conditioning, a form of associative learning whose neural circuitry is relatively well understood, that may be particularly suited for addressing this question. We first review the evidence suggesting that fear conditioning is mediated by changes in synaptic strength at sensory inputs to the lateral nucleus of the amygdala. We then discuss several outstanding questions that will be important for future research on the role of synaptic plasticity in fear learning. The results gained from these studies may shed light not only on fear conditioning, but may also help unravel more general cellular mechanisms of learning and memory. (c) 2006 Elsevier Ltd. All rights reserved.
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