期刊
JOURNAL OF NEUROVIROLOGY
卷 13, 期 3, 页码 284-289出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/13550280701329646
关键词
arbovirus; DNA; encephalitis; mucosal; oral; prime-boost; Sindbis virus; vaccination
Arboviruses of the families Togaviridae and Flaviviridae are widely distributed and are important causative agents of viral encephalitis, a severe and often fatal disease. The only internationally available vaccine against these diseases is expensive and laborious to manufacture and difficult to administer. Therefore, new vaccines are required against these pathogens. This study investigates the use of a DNA- prime, orally delivered protein boost vaccination strategy against viral encephalitis. This vaccination strategy was immunogenic and provided partial protection against viral encephalitis in a murine model, demonstrating the possible applicability of this vaccination strategy for the management of endemic encephalitis.
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