期刊
MAGNETIC RESONANCE IN MEDICINE
卷 57, 期 1, 页码 22-28出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.21085
关键词
obesity; intramyocellular lipids; spectroscopic imaging; skeletal muscle; quantitation
Quantification of intramyocellular lipids (IMCL) in obese subjects by single-voxel spectroscopy (SVS) or conventional spectroscopic imaging (SI) often fails due to overlap of IMCL spectral lines by extra myocellular lipids (EMCL), and signal contamination from subcutaneous fat and bone marrow. This study demonstrates that these problems can be solved by high-resolution SI with 128 phase-encoding steps and a read gradient during acquisition. The small voxels obtained in this way facilitated differentiation between EMCL and IMCL. This method offers the possibility of studying different muscle groups and the variation of lipids within one muscle.
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