期刊
CEREBRAL CORTEX
卷 18, 期 1, 页码 1-12出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhm026
关键词
behavior; cognition; dopamine; knockout; LTP; memory; water maze
Recent evidence suggests that glutamatergic and dopaminergic afferents must be activated to induce persistent long-term potentiation (LTP) in the hippocampus. Whereas extensive evidence supports the role of glutamate receptors in long-lasting synaptic plasticity and spatial learning and memory, there is less evidence regarding the role of dopamine receptors in these processes. Here, we used dopamine D-1 receptor knockout (D1R-/-) mice to explore the role of D1R in hippocampal LTP and its associated gene expression. We show that the magnitude of early and late phases of LTP (E-LTP and L-LTP) was markedly reduced in hippocampal slices from D1R-/- mice compared with wild-type mice. SCH23390, a D-1>/D5R antagonist, did not further reduce L-LTP in D1R-/- mice, suggesting that D(5)Rs are not involved. D1R-/- mice also showed a significant reduction of D1R-induced potentiation of N-Methyl-D-aspartic acid-mediated currents, via protein kinase activated by cyclic adenosine 3',5'-monophosphate activation. Finally, LTP-induced expression of the immediate early genes zif268 and arc in the hippocampal CA1 area was abolished in D1R-/- mice, and these mice showed impaired learning. These results indicate that D1R but not D5R are critical for hippocampal LTP and for the induction of Zif268 and Arc, proteins required for the transition from E-LTP to L-LTP and for memory consolidation in mammals.
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