期刊
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
卷 54, 期 6, 页码 356-367出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/070674370905400603
关键词
tobacco; nicotine; mental illness; mechanisms; comorbidity; psychiatric disorders; substance use disorders; treatment; epidemiology
类别
资金
- National Institute on Drug Abuse [R01-DA-13672, R01-DA-14039, R01-DA-15757, K02-DA-16611]
- National Alliance for Research on Schizophrenia and Depression
- Canadian Tobacco Control Research Initiative-Canadian Institutes of Health Research (CIHR) [19588]
- University of Toronto
- CAMH
- CIHR
- National Cancer Institute [R01-CA-96836, R01-CA-109250]
- Pfizer
- Sepracor
- Targacept
- Sanofi-aventis
We discuss potential explanations for the high prevalence of tobacco use and tobacco dependence (TD) in people with mental health and addictive (MHA) disorders. The biopsychosocial basis for this comorbidity is presented, integrating evidence from epidemiologic and clinical studies. We also review evidence that suggests a shared vulnerability related to biological, genetic, and environmental factors may be the most parsimonious mechanism to explain the association between TD and MHA disorders. Finally, we review the examples of various MHA disorders that are associated with TD, and suggest avenues for new investigation that could aid in the development of rationale and more effective treatments for tobacco and MHA disorder comorbidities.
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