期刊
NATURE NEUROSCIENCE
卷 11, 期 1, 页码 16-18出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn2016
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资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH071702, R01MH052090] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH 71702, P50 MH071702-01A2, MH 52090, R01 MH052090, P50 MH071702, R01 MH052090-05] Funding Source: Medline
A major controversy in memory research concerns whether recognition is subdivided into distinct cognitive mechanisms of recollection and familiarity that are supported by different neural substrates. Here we developed a new associative recognition protocol for rats that enabled us to show that recollection is reduced, whereas familiarity is increased following hippocampal damage. These results provide strong evidence that these processes are qualitatively different and that the hippocampus supports recollection and not familiarity.
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