期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 10, 页码 788-801出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2416
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资金
- US National Institutes of Health
- National Cancer Institute
- Center for Cancer Research, USA
- NATIONAL CANCER INSTITUTE [ZIABC011106, ZIABC009273, Z01BC011111] Funding Source: NIH RePORTER
Following successful gene rearrangement at alpha beta T-cell receptor (TCR) loci, developing thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection event, which is known as positive selection, to identify cells that express TCRs with potentially useful ligand specificities. Positively selected thymocytes must then differentiate into either CD4(+) helper T cells or CD8(+) cytotoxic T cells, a crucial decision known as CD4/CD8-lineage choice. In this Review, we summarize recent advances in our understanding of the cellular and molecular events involved in lineage-fate decision and discuss them in the context of the major models of CD4/CD8-lineage choice.
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