期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 4, 页码 269-278出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2278
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- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI047990] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI047990, R01 AI047990-04, R01 AI047990] Funding Source: Medline
The conventional wisdom is that cell-surface receptors interact with ligands expressed on other cells to mediate cell-to-cell communication (trans interactions). Unexpectedly, it has recently been found that two classes of receptors specific for MHC class I molecules not only interact with MHC class I molecules expressed on opposing cells, but also with those on the same cell. These cis interactions are a feature of immunoreceptors that inhibit, rather than activate, cellular functions. Here, we review situations in which cis interactions have been observed, the characteristics of receptors that bind in trans and cis, and the biological roles of cis recognition.
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