期刊
NATURE REVIEWS CANCER
卷 8, 期 3, 页码 212-226出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2345
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资金
- Intramural NIH HHS [Z01 BC010478] Funding Source: Medline
- NCI NIH HHS [R01 CA113865-02, R01 CA113865, R01 CA113865-03, R21 CA087311-02, R01 CA113865-01A2, R21 CA087311-01, R21CA87311] Funding Source: Medline
- PHS HHS [K23 017791-01A1] Funding Source: Medline
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [Z01DE000074] Funding Source: NIH RePORTER
Numerous components and pathways are involved in the complex interplay between cancer cells and their environment. The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein-small integrin-binding ligand N-linked glycoproteins (SIBLINGs)-are emerging as important players in many stages of cancer progression. From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.
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