期刊
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
卷 91, 期 7, 页码 562-569出版社
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/cjpp-2012-0309
关键词
theanine; caffeine; cerebral ischemia-reperfusion; synergism; neuroprotection
资金
- Qing-Lan Project of Jiangsu Province
- Liu Da Ren Cai Gao Feng Project of Jiangsu Province [2011-YY-13]
- Industrialization of Scientific Research Promotion Projects of Universities and Colleges in Jiangsu Province [2011-16]
- Natural Science Fund for Universities and Colleges in Jiangsu Province [11KJB350005]
- Foundation of School of Pharmacy in Xuzhou Medical College [2011YKJ004]
- Foundation of Xuzhou Medical College Key Laboratory of Tumor Biology Therapy [C0904, JSBL0803, C0903]
- Science and Technology Plan Projects of Xuzhou [XF11C037, XF11C062, XZZD1227, XZZD1219]
- Superiority Academic Discipline Construction Project of Jiangsu Higher Education Institutions
- Post-doctoral Fund in Jiangsu Province [1201036B]
- research project of Xuzhou [BRA201205]
Theanine and caffeine, 2 naturally occurring components in tea, have repeatedly been shown to deliver unique cognitive benefits when consumed in combination. In this study, we assessed the beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral damage in rats. Theanine and caffeine had no effect on physiological variables, including pH, partial pressures of oxygen (PaO2) and carbon dioxide (PaCO2), mean arterial blood pressure, plasma glucose, or regional cerebral blood flow. Treatment with theanine (1 mg/kg body mass, intraperitoneal injection) alone significantly reduced cerebral infarction induced by cerebral ischemia-reperfusion, but caffeine (10 mg/kg, intravenous administration) alone only had a marginal effect. However, the combination of theanine plus caffeine resulted in a significant reduction of cerebral infarction and brain edema compared with theanine monotherapy. Meanwhile, increased malondialdehyde levels as well as decreased superoxide dismutase activity, glutathione peroxidase activity, and glutathione levels observed in the cerebral cortex after cerebral ischemia-reperfusion were significantly ameliorated by the combination therapy. Furthermore, the elevated inflammatory response levels observed in the cortex after cerebral ischemia-reperfusion were markedly attenuated by the combined treatment. Thus, it is suggested that the neuroprotective potential of a combination therapy with theanine and caffeine against cerebral ischemia-reperfusion is partly ascribed to their antioxidant and anti-inflammatory properties.
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