A series of 4 cases of distinct keratopathy secondary to dysproteinemia: Immunotactoid keratopathy

Objective: To describe a series of 4 cases of immunotactoid keratopathy (ITK) secondary to monoclonal gammopathy. Design: Multicentre retrospective case series of 4 patients. Participants: Eight eyes of 4 patients presenting to a cornea service with ITK. Methods: Retrospective case series of 4 patients referred between 2011 and 2013 for bilateral corneal opacities. Work-up including serum protein electrophoresis was performed, and slit-lamp photographs were obtained. Results: After investigation, diagnoses of ITK secondary to monoclonal gammopathy of unknown significance were established in 3 cases. In 1 patient, the diagnosis of monoclonal gammopathy of unknown significance was established prereferral. Conclusions: ITK secondary to plasma cell disorders can clinically resemble a broad category of disease processes and must be considered when evaluating patients with bilateral peripheral stromal opacities. Our series validates previously proposed classification schemes for these opacities.