期刊
JOURNAL OF BIOCHEMISTRY
卷 143, 期 3, 页码 287-293出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvn013
关键词
epigenetic code; histone H1; histone modification; histone variant; linker histone
Recently, the existence of a 'histone code' has been proposed to explain the link between the covalent chemical modification of histone proteins and the epigenetic regulation of gene activity. Although the role of the four 'core' histones has been extensively studied, little is known about the involvement of the linker histone, histone H1 and its variants, in this code. For many years, few sites of chemical modification had been mapped in linker histones, but this has changed recently with the use of functional proteomic techniques, principally mass spectrometry, to characterize these modifications. The functionality of many of these sites, however, remains to be determined.
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