期刊
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
卷 39, 期 4, 页码 416-435出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0317167100013937
关键词
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资金
- Canadian Institutes of Health Research
- Alberta Heritage Foundation for Medical Research (AHFMR) studentship
- AHFMR Dr. Lionel E. McLeod Health Research Scholarship
Neuropathic pain often fails to respond to conventional pain management procedures. Here we review the aetiology of neuropathic pain as would result from peripheral neuropathy or injury. We show that inflammatory mediators released from damaged nerves and tissue are responsible for triggering ectopic activity in primary afferents and that this, in turn, provokes increased spinal cord activity and the development of 'central sensitization'. Although evidence is mounting to support the role of interleukin-1 beta, prostaglandins and other cytokines in the onset of neuropathic pain, the clinical efficacy of drugs which antagonize or prevent the actions of these mediators is yet to be determined. Basic science findings do, however, support the use of pre-emptive analgesia during procedures which involve nerve manipulation and the use of anti-inflammatory steroids as soon as possible following traumatic nerve injury.
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