期刊
JOURNAL OF DIABETES AND ITS COMPLICATIONS
卷 29, 期 5, 页码 644-649出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2015.04.001
关键词
Diabetes mellitus; Diabetic neuropathy; Quality of life; Neuropathy severity; Undisclosed neuropathy
资金
- POSDRU grant [159/1.5/S/138776]
- Worwag Pharma GmbH&Co.KG, Romanian Rep Office
Aims: The objective of this cross-sectional survey was to capture undiagnosed neuropathy in Romanian patients with self-reported diabetes using Norfolk QoL-DN as a screening tool and to assess its impact on quality of life (QoL). Methods: 25,000 Romanian-translated, validated Norfolk QoL-DN questionnaires were distributed between June and December 2012. 21,261 patients who self-reported diabetes and answered questions related to neuropathy, ulceration, gangrene and amputation were included in the analysis. Results: 52% of diabetic patients (n = 6615) who answered no to the question Do you have neuropathy? had total QoL scores above the cut-off, suggesting the presence of diabetic neuropathy. 13,854 (65.2%) patients answered yes to the question Do you have neuropathy? and 3,150 (14.8%) reported at least one episode of ulceration, gangrene or amputation. Total QoL score was 3-fold higher (worse) for patients who answered yes to the question Do you have neuropathy? than for those who answered no (38.39 vs. 13.71; p < 0.001) and 1.4-fold worse for patients who reported ulceration, gangrene or amputation than for those who did not report any of these (50.38 vs. 34.87; p < 0.001). Conclusions: We found a high prevalence of undisclosed diabetic neuropathy in this population and showed that neuropathy severity has an increasing impact on total QoL and its domains. (C) 2015 Elsevier Inc. All rights reserved.
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