期刊
SPINAL CORD
卷 46, 期 1, 页码 26-32出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.sc.3102054
关键词
adrenaline; cortisol; prostaglandin; immune system; exercise; spinal cord injuries
Design: Non-randomized study. Objective: To determine natural killer cell cytotoxic activity (NKCA) to 2-h arm ergometer exercise in persons with spinal cord injuries (SCI) and the underlying mechanism of such response. Setting: University of Occupational and Environmental Health, Japan. Methods: We examined NKCA response to 2-h arm crank ergometer exercise at 60% of maximum oxygen consumption (VO2max) in SCI and able-bodied persons. NKCA and plasma concentrations of prostaglandin E-2 (PGE(2)), adrenaline and cortisol were measured before, during and immediately after the exercise. The study included seven subjects with SCI between Th11 and L4 and six able-bodied persons. Results: NKCA in able-bodied subjects increased (P < 0.05) at 60 min of exercise and immediately after the exercise, and remained elevated up to 2 h after exercise. However, NKCA in SCI decreased (P < 0.05) immediately after exercise but recovered at 2 h after exercise. Plasma adrenaline in both groups increased significantly (P < 0.05) immediately after exercise and returned to baseline level 2 h after the exercise. Plasma cortisol in both groups remained constant throughout the study. In SCI, PGE(2) significantly increased immediately after 2 h exercise and returned to the baseline level 2 h after exercise; however, it remained unchanged during the test in able-bodied subjects. Conclusion: Our results suggested that increase of PGE(2) in SCI partially contributes to NKCA.
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