Outcome of Stereotactic Radiotherapy for Patients with Uncontrolled Acromegaly

Objective: Linear accelerator based stereotactic radiation therapy (SRT) has been used for the treatment of pituitary tumours; however, little is known concerning the use of this modality for the treatment of patients with acromegaly. We have prospectively studied the short-term outcome of SRT in 12 acromegaly patients who failed to achieve biochemical remission despite surgery and/or pharmacologic therapy. Methods: We identified all patients who had biochemically uncontrolled acromegaly and were treated with SRT between April 2003 and December 2006. All patients were followed prospectively based on a pre-defined protocol that included Goldman visual field examination, MRI of the Sella, and pituitary hormone testing at 3, 6, 12 months, and then yearly. Results: A total of 12 patients with acromegaly were treated with SRT. There were 9 females and the median age of the group was 50 years. The median follow-up was 28.5 months during which time the mean tumor volume decreased by 40%, the median GH fell from 4.1 mu g/L to 1.3 mu g/L (p=0.003) and the median IGF- 1 dropped more than half from 545.5 mu g/L to 260.5 mu g/L (p=0.002). Four patients achieved normal, while an additional 2 achieved near-normal, IGF- 1 levels. One patient was able to discontinue and two were able to reduce their acromegaly medications while maintaining a normal IGF- 1. A new pituitary hormonal deficit was found at 24 months in one patient who developed hypoadrenalism requiring corticosteroid replacement. Conclusion: Based on our early experience, we believe that SRT should be considered in treating patients with uncontrolled acromegaly.