期刊
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
卷 35, 期 5, 页码 630-637出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0317167100009434
关键词
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资金
- Taipei Veterans General Hospital [V96ER3-004, V96C1-123, V97ER3-006, VGHUST97-PG24]
- National Science Council [NSC-95-2314-B-010-030-MY3, NSC-96-2628-B010-030-MY3, NSC-94-2811-B-010-009]
Objective: This study is aimed to explore the frequency characteristics of pain-evoked neuromagnetic responses in the secondary somatosensory (SIT) cortices. Methods: Thulium-laser nociceptive stimuli to the left hand dorsum of 10 right-handed healthy adults. The pain stimuli were rated as mild, moderate. and severe levels according to subjects' reports on a 10-point visual analog scale. We analyzed their cortical responses with wavelet-based frequency analyses and equivalent current dipole (ECD) modeling. Results: For each pain level, we found ail increase of theta (4-8 Hz) and alpha (8-13 Hz) Power in bilateral SII areas at 180-210 ms after stimulus onset. The power was larger for the moderate than for the mild pain level (p < 0.05), but there was no statistical power difference of these oscillations between moderate and severe pain stimulus conditions (p = 0.7). Within the SII area. we did not observe particular difference in theta and alpha ECD locations between varying pain level conditions. Conclusions: The 4-13 Hz activities, peaking from 180 to 2 10 Ills, arc Oscillatory correlates of SII activation in response to nociceptive stimulation, but their power may code the magnitude of pain stimuli Only LIP to moderate level. as rated subjectively. This measure could be potentially used to evaluate SII activation in further pain studies.
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