期刊
HEREDITY
卷 100, 期 3, 页码 240-252出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.hdy.6801074
关键词
Bayesian methods; complex traits; experimental crosses; Markov chain Monte Carlo algorithms; quantitative trait loci
资金
- NIGMS NIH HHS [GM069430, R01 GM069430] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069430] Funding Source: NIH RePORTER
Many complex human diseases and traits of biological and/or economic importance are determined by interacting networks of multiple quantitative trait loci (QTL) and environmental factors. Mapping QTL is critical for understanding the genetic basis of complex traits, and for ultimate identification of genes responsible. A variety of sophisticated statistical methods for QTL mapping have been developed. Among these developments, the evolution of Bayesian approaches for multiple QTL mapping over the past decade has been remarkable. Bayesian methods can jointly infer the number of QTL, their genomic positions and their genetic effects. Here, we review recently developed and still developing Bayesian methods and associated computer software for mapping multiple QTL in experimental crosses. We compare and contrast these methods to clearly describe the relationships among different Bayesian methods. We conclude this review by highlighting some areas of future research.
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