期刊
JOURNAL OF DERMATOLOGY
卷 42, 期 5, 页码 528-531出版社
WILEY-BLACKWELL
DOI: 10.1111/1346-8138.12810
关键词
digital ulcers; endothelial cells; systemic sclerosis; vascular smooth muscle cells; vaspin
类别
资金
- Ministry of Health, Labor and Welfare of Japan
Vaspin is an adipokine implicated in vascular inflammation and remodeling. We herein evaluated the clinical correlation of serum vaspin levels in systemic sclerosis (SSc). Consistent with previous reports, 12% of subjects exhibited serum vaspin levels over 10ng/mL, likely due to genetic effects. Excluding these subjects, despite no difference between SSc and control subjects, serum vaspin levels were significantly decreased in SSc patients with digital ulcers compared with those without, suggesting the potential contribution of vaspin to digital ulcers of this disease.
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