期刊
ACS CHEMICAL BIOLOGY
卷 10, 期 11, 页码 2564-2569出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.5b00566
关键词
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资金
- JGC-S Scholarship Foundation
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [26410176, 243925]
- Grants-in-Aid for Scientific Research [26410176] Funding Source: KAKEN
Human telomere DNA (Htelo) and telomeric repeat-containing RNA (TERRA) are integral telomere components containing the short DNA repeats d(TTAGGG) and RNA repeats r(UUAGGG), respectively. Htelo and TERRA form G-quadruplexes, but the biological significance of their G-quadruplex formation in telomeres is unknown. Compounds that selectively bind G-quadruplex DNA and RNA are useful for understanding the functions of each G-quadruplex. Here we report that engineered Arg-Gly-Gly repeat (RGG) domains of translocated in liposarcoma containing only Phe (RGGF) and Tyr (RGGY) specifically bind and stabilize the G-quadruplexes of Htelo and TERRA, respectively. Moreover, RGGF inhibits trimethylation of both histone H4 at lysine 20 and histone H3 at lysine 9 at telomeres, while RGGY inhibits only H3 trimethylation in living cells. These findings indicate that G-quadruplexes of Htelo and TERRA have distinct functions in telomere histone methylation.
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