期刊
EXPERT OPINION ON DRUG DELIVERY
卷 5, 期 1, 页码 105-117出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425247.5.1.105
关键词
biomacromolecule; cell-penetrating peptides; colloidal carriers; drug delivery; endocytosis; intracellular delivery; nucleic acid; peptide; protein; transduction; translocation
资金
- Danish Research Council for Technology and Production Sciences
During the last decade, cell-penetrating peptides have been investigated for their ability to overcome the plasma membrane barrier of mammalian cells for the intracellular or transcellular delivery of cargoes as diverse as low molecular weight drugs, imaging agents, oligonucleotides, peptides, proteins and colloidal carriers such as liposomes and polymeric nanoparticles. Their ability to cross biological membranes in a non-disruptive way without apparent toxicity is highly desired for increasing drug bioavailability. This review provides an overview of the application of cell-penetrating peptides as transmembrane drug delivery agents, according to the recent literature, and discusses critical issues and future challenges in relation to fully understanding the fundamental principles of the cell-penetrating peptide-mediated membrane translocation of cargoes and the exploitation of their therapeutic potential.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据