期刊
ANALYTICAL METHODS
卷 7, 期 16, 页码 6804-6809出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ay01437a
关键词
-
资金
- National Natural Science Foundation of China [21275046, 21475039]
- Natural Science Foundation of Hunan Province [2015JJ2028]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130161110027]
- Program for New Century Excellent Talents in University [NCET-12-0161]
In this contribution, tandem mass spectrometry coupled with liquid chromatography (LC-MS/MS) was combined with the multiplicative effects model for mass spectroscopy (MEMMS) to quantitatively determine three hormones (i.e. estrone, hydrocortisone and progesterone) in cosmetics (toner and essence emulsion). The adoption of the MEMMS model in the analysis of LC-MS/MS data was to address the problem of sensitivity and signal instability of LC-MS/MS over time caused by the gradual fouling of the ion source, vacuum instability, drifting of baseline, ion suppression, etc. Experimental results showed that the MEMMS model could effectively mitigate the detrimental effects of the signal instability of LC-MS/MS over time, and achieve quite accurate quantitative results for estrone, hydrocortisone, and progesterone in both toner and essence emulsion samples with average relative prediction error values no larger than 10.0%, which were far lower than the corresponding values (11.5-67.4%) of the conventional univariate internal standard calibration method based on peak height ratios between the peak of the target analytes and that of the internal standard.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据