期刊
EXPERT OPINION ON DRUG DISCOVERY
卷 3, 期 1, 页码 83-97出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17460441.3.1.83
关键词
animal model; Caenorhabditis elegans; dystonia; experimental therapeutics; hamster; mouse; primate; rat
资金
- Bachmann-Strauss Dystonia and Parkinson Foundation
- Dystonia Medical Research Foundation
- [NS28384]
- [NS40470]
Dystonia is a neurological disorder characterized by involuntary twisting movements and unnatural postures. There are many different forms of dystonia, which affect over three million people worldwide. Effective treatments are available only for a minority of patients, so new treatments are sorely needed. Several animal species have been used to develop models for different forms of dystonia, each with differing strengths and weaknesses. This review outlines the strategies that have been used to exploit these models for drug discovery. Some have been used to dissect the pathogenesis of dystonia for the identification of molecular targets for intervention. Others have been used for the empirical identification of candidate drugs. Therefore, the animal models provide promising new tools for developing better treatments for dystonia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据