期刊
出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03601230701735110
关键词
mIMCD3 cells; HEK293 cells; paraquat; hyperosmolality
资金
- NIDDK NIH HHS [R01 DK 59470] Funding Source: Medline
- NIEHS NIH HHS [P42 ES 04699, P30 ES 05707] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK059470] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES005707, P42ES004699] Funding Source: NIH RePORTER
The present study investigates renal inner medullary collecting duct (mIMCD3) cells and human embryonic kidney cells (HEK293) for evaluation of cytotoxicity of nephrotoxic compounds. The 24 h LC50 values for cisplatin, paraquat and ibuprofen in mIMCD3 cells were 135, 155 and 3600 mu M, respectively. The 24 h LC50 values for paraquat and ibuprofen in HEK293 cells were 180 and 1000 mu M, respectively. Effects of hyperosmolality on cytotoxicity of paraquat were additive in mIMCD3 cells. These data demonstrate that renal hyperosmolality has an additive effect on cytoxicity of paraquat.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据