期刊
EXPERT OPINION ON DRUG DISCOVERY
卷 3, 期 1, 页码 1-10出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/17460441.3.1.1
关键词
3D; angiogenesis; breast; cancer; esophagusoncology; organotypic; skin; spheroid; therapy; tissue engineering
Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.
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