期刊
JOURNAL OF DENTISTRY
卷 43, 期 3, 页码 317-326出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jdent.2015.01.009
关键词
Self-healing dental composite; Microcapsules; Polymerizable healing liquid; Antibacterial; Mechanical properties; Fracture toughness recovery
资金
- NIH from Shandong Provincial Natural Science Foundation in China [R01 DE17974, ZR2014HM073]
- University of Maryland School of Dentistry
Objectives: Fracture and secondary caries are the primary reasons for dental restoration failure. The objective of this study was to develop a self-healing composite to heal cracks, while containing dimethylaminohexadecyl methacrylate (DMAHDM) for antibacterial function and nanoparticles of amorphous calcium phosphate (NACP) for remineralization. Methods: Microcapsules were synthesized with poly(urea-formaldehyde) (PUF) shells containing triethylene glycol dimethacrylate (TEGDMA) and N, N-dihydroxyethyl-p-toluidine (DHEPT) as healing liquid. Composite contained 20 mass% of NACP and 35% glass fillers. In addition, composite contained 0%, 2.5%, 5%, 7.5%, or 10% of microcapsules. A single edge Vnotched beam method measured fracture toughness (KIC) and self-healing efficiency. A dental plaque microcosm biofilm model was used to test the antibacterial properties. Results: Incorporation of microcapsules up to 7.5% into the composite did not adversely affect the mechanical properties (p > 0.1). Successful self-healing was achieved, with KIC recovery of 65-81% (mean +/- sd; n = 6) to regain the load-bearing capability after composite fracture. The self-healing DMAHDM-NACP composite displayed a strong antibacterial potency, inhibiting biofilm viability and lactic acid production, and reducing colony-forming units by 3-4 orders of magnitude, compared to control composite without DMAHDM. Conclusions: A dental composite was developed with triple benefits of self-healing after fracture, antibacterial activity, and remineralization capability for the first time. (C) 2015 Elsevier Ltd. All rights reserved.
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