DABCO-functionalized mesoporous SBA-15: an efficient and recyclable catalyst for the synthesis of spiro-pyranoxindoles as antioxidant agents

A series of spiro-pyranoxindole derivatives were prepared in good yields via a three-component reaction of isatins with activated methylene reagents and kojic acid using 1,4-diazabicyclo[2.2.2]octane (DABCO) immobilized on mesoporous SBA-15 as a heterogenized organocatalyst in aqueous media. The synthesized compounds were evaluated for their antioxidant activity by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay.