期刊
CANADIAN JOURNAL OF CHEMISTRY
卷 92, 期 3, 页码 243-249出版社
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/cjc-2013-0490
关键词
supramolecular; cucurbit[7]uril; steroidal neuromuscular blocking agents; reversal agent; host-guest complex
资金
- Natural Sciences and Engineering Research Council of Canada
- Queen's University
The complexations of three steroidal neuromuscular blocking agents, rocuronium, vecuronium, and pancuronium, by the cucurbit[7]uril host molecule have been investigated in aqueous solution using H-1 NMR spectroscopy and ESI mass spectrometry. The CB[7] binds to each of the two terminal cationic N-heterocyclic groups by means of ion-dipole interactions and hydrophobic effects, with stability constants in the order of vecuronium > pancuronium > rocuronium. This trend is different from those observed for the anionic substituted gamma-cyclodextrin (Sugammadex), currently employed as a neuromuscular blockade reversal agent, and an acylic glycoluril tetramer (Calabadion), recently reported to reverse both steroidal and benzylisoquinolium neuromuscular blocking agents in rats.
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