期刊
CANADIAN JOURNAL OF CHEMISTRY
卷 91, 期 10, 页码 974-981出版社
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/cjc-2013-0165
关键词
nanocrystalline cellulose; surface functionalization; TEMPO oxidation; EDC/NHS coupling; characterization; aminated NCC
资金
- National Institute for Nanotechnology of the National Research Council of Canada
In this present work, terminal amino-functionalized nanocrystalline cellulose derivatives were prepared using a simple two-step protecting group-free protocol under aqueous reaction conditions at room temperature. Carboxylate groups were first introduced onto the surface of nanocrystalline cellulose (NCC) via a TEMPO-mediated oxidation. Then, reaction of surface-carboxylated NCC with bifunctional amines of small alkyl chain length by EDC/NHS-mediated coupling furnished the desired aminated NCC via an amide linkage. Surface covalent functionalization was confirmed by Fourier transform infrared spectroscopy, elemental analysis, and X-ray photoelectron spectroscopy. Size, surface charge, morphology, and thermal properties were obtained by various techniques. STEM images revealed no change in structure and morphology of the materials after TEMPO-mediated oxidation but a slight agglomeration was observed after surface covalent functionalization with diamines. While amide linkage confers stability, terminal primary amine groups on the surface of NCC represent a versatile reactive functional group for bioconjugation with other biomolecules for potential biomedical applications.
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