Multi-component supramolecular synthesis of spirooxindoles catalyzed by β-cyclodextrin in water

A neutral and efficient one-pot three-component aqueous-phase synthesis is developed for various spirooxindole derivatives from isatin, malononitrile, and 1,3-dicarbonyl compounds in high yields by supramolecular catalysis involving beta-cyclodextrin. The beta-cyclodextrin can be recovered and reused a number of times without any loss of activity.