期刊
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
卷 87, 期 11, 页码 1636-1640出版社
NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS
DOI: 10.1139/V09-123
关键词
Guttiferae; Garcinia cowa; cowaxanthone F; anti-inflammatory activity; antioxidant activity
资金
- Prince of Songkla University
- Commission on Higher Education (CHE-RES-RG)
- Center for Innovation in Chemistry (PERCH-CIC)
- Royal Thai Government
A new tetraoxygenated xanthone, cowaxanthone F (1), as well as four known compounds, morelloflavone (2), volkensiflavone (3), morelloflavone-7 ''-O-glucoside (fukugiside, 4), and 1,6-dihydroxyxanthone (5), were isolated from the crude acetone extract of the twigs of Garcinia cowa (Guttiferae). All compounds (1-5) were tested for antioxidant activity against DPPH (diphenylpicrylhydrazyl), hydroxyl, and superoxide radicals; only morelloflavone (2) and morelloflavone-7 ''-O-glucoside(4) exhibited high potency. Eight tetraoxygenated xanthones from the fruits of G. cowa, cowaxanthones A-D (6-9), cowanin (15), alpha-mangostin (16), mangostanin (17), and cowanol (18), were also investigated for anti-inflammatory Activity using ethyl phenylpropiolate (EPP)-induced car edema. Assessment at 30, 60, and 120 min revealed that cowaxanthones B-D (7-9), cowanin (15), and alpha-mangostin (16) exhibited significant anti-inflammatory activity when compared to phenylbutazone, while cowaxanthone A (6), mangostanin (17), and cowanol (18) showed less activity.
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