期刊
MOLECULAR ONCOLOGY
卷 1, 期 4, 页码 406-412出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molonc.2007.12.001
关键词
Prognostic; Predictive; Epidermal growth factor receptor; Non-small lung cancer; Erlotinib; Smoking; Histology
类别
It would be helpful to have factors that could identify patients who will, or will not, benefit from treatment with specific therapies. Ideally, these should be molecular-based factors. When results with molecular-based factors are disappointing, physicians often use clinical character-is tics to make treatment decisions. Several characteristics have been suggested to predict sensitivity to epidermal growth factor receptor inhibitors in patients with non-small lung cancer, including gender, histology, smoking history. This report demonstrates that gender and histology are actually prognostic, rather than predictive factors. Before biomarkers or clinical characteristics are included in guidelines for selecting patients for specific treatments, it is imperative that the prognostic effects of these factors are distinguished from their ability to predict a differential clinical benefit from the specific treatment. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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