C-reactive protein: Risk factor, biomarker and/or therapeutic target?

The inflammatory biomarker high-sensitivity C-react we protein (hsCRP) has been proposed is a novel instrument to assess cardiovascular risk, to determine the need for stain therapy in specific individuals otherwise not deemed to meet current criteria, and to represent a potential target of treatment. CRP is predominantly secreted by the liver and adipose tissue in response to inflammatory stress and is regulated, in great part, by interleukin-6. The issue of CRP MS a causal factor (rather than a biomarker) has been addressed by three types of studies: animal models, in which CRP was injected; transgenic to ice over-expressing human CRP; and Mendelian randomization studies. All indicate that CRP may not have a direct role in Promoting atherosclerosis hut, instead, serves is a marker of vascular inflammation and the presence of atherosclerosis. Several clinical studies have shown that individuals reaching both low-density lipoprotein cholesterol (LDL-C) and is a,RP targets (LDL-C less than 2.0 mmol/L and hsCRP less than 2 mg/L) have the lowest event rate, suggesting that CRP may become a secondary target of treatment after LPL-C. The Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuviistatin (JUPITER) study showed that apparently healthy men and woolen with elevated hsCRP, but normal LDL-C (less than 3.4 mmol/L), had an overall 44% reduction in the primary end points with rosuvastatin 20 mg/day. The results of this study have now been incorporated in the new Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease.