期刊
CANADIAN JOURNAL OF CARDIOLOGY
卷 25, 期 4, 页码 213-218出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0828-282X(09)70064-9
关键词
Cardiomyopathy; Cardiovascular death; Iron overload; Thalassemia
资金
- Thailand Research Fund [RMU 4980001]
Patients with thalassemia major have inevitably suffered from complications of the disease, due to iron overload. Among such complications, cardiomyopathy is the leading cause of morbidity and mortality (63.6% to 71%). The major causes of death in this group of patients are congestive heart failure and fatal cardiac tachyarrhythmias leading to sudden cardiac principal mechanism of death. The free radical-mediated pathway is the pi iron toxicity. The consequent series of events caused by iron overload lead to catastrophic cardiac effects. The authors review the electrophysiological and molecular mechanisms, pathophysiology and correlated clinical insight of heart failure and arrhythmias in iron overload thalassemic cardiomyopathy.
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