期刊
CRITICAL REVIEWS IN IMMUNOLOGY
卷 28, 期 4, 页码 325-339出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.v28.i4.40
关键词
IL-7; IL-15; IL-7 receptor alpha; IL-15 receptor alpha; IL-2/15 receptor beta; cytokines; T-cell homeostasis; adjuvant
类别
资金
- National Institute of Health [AG028069, AG030834, AR049444, AI075157]
- Korea Science and Engineering Foundation through the Rheumatism Research Center [R11-2002-098-05001-0]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI075157] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [K08AR049444] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R21AG030834, R01AG028069] Funding Source: NIH RePORTER
Cytokines IL-7 and IL-15 are essentially involved in T-cell homeostasis. IL-7 is required for developing mature T cells in the thymus, whereas in the periphery, it promotes the survival of naive and memory T cells by upregulating the antiapoptotic molecule Bcl-2. IL-15 potently induces the proliferation of memory CD8(+) T cells independently of antigen and augments their effector function. Although IL-7 and IL-15 may help to defend the host against microorganisms and tumors by promoting T-cell immunity, dysregulated production of IL-7 and IL-15 can be harmful. In fact, increased levels of IL-15 in the circulation and inflamed tissues have been reported in various autoimmune diseases, including rheumatoid arthritis (RA), possibly contributing to the pathogenesis. In addition, IL-7, which may induce the production of inflammatory cytokines from T cells and monocytes, are found to be elevated in the joints of patients with RA. Here, we review what is currently known about the roles of these cytokines in T-cell immunity, in general, as well as in RA, in particular, focusing on recent discoveries.
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