期刊
JOURNAL OF CYSTIC FIBROSIS
卷 14, 期 3, 页码 341-346出版社
ELSEVIER
DOI: 10.1016/j.jcf.2014.10.008
关键词
Cystic fibrosis; Pseudomonas aeruginosa; Environmental source; Household drains; Human home
资金
- National Science Foundation [DEB-0950361]
Background: For patients with cystic fibrosis (CF) Pseudomonas aeruginosa infection is a major contributor to progressive lung disease. While colonizing strains are thought to be primarily environmental, which environments are important in lung colonization is unclear. Methods: We took 11,674 samples from a broad range of sites over 3-8 visits to homes with (7) and without (8) CF patients. Results: Twenty-eight percent of sampled drains yielded P. aeruginosa at least once, and a general mixed linear model estimated that 6.3% of samples from drains yield P. aeruginosa. This is more than eight times the estimated recovery from any other type of household environment. Conclusions: These findings implicate drains as important potential sources of P. aeruginosa infection. They suggest that maximizing P. aeruginosa control efforts for drains would reduce exposure with minimal extra burden to CF patients and families. (C) 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
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