Weight change and cancer risk in a cohort of more than 65,000 adults in Austria

Background: To investigate relations between weight loss or weight gain and the incidence of cancer. Patients and methods: Weight change was assessed in a population-based cohort of > 65 000 Austrian adults (28 711 men and 36 938 women) for a period of 7 years, after which participants were followed for incident cancers over 8 years on average. Incident cancers (other than nonmelanoma skin cancers) were ascertained by a population-based cancer registry (n = 3128). Cox proportional hazards models were used to estimate hazard rate ratios (HRs) stratified by age and adjusted for smoking, occupational group, blood glucose and body mass index at baseline. Results: In both men and women, neither weight loss nor weight gain was clearly associated with the incidence of all cancers combined. Weight loss (> 0.10 kg/m(2)/year) was inversely associated with colon cancer in men [HR 0.50; 95% confidence interval (CI) 0.29-0.87], while high weight gain (>= 0.50 kg/m(2)/year) was inversely associated with prostate cancer (HR 0.43; 95% CI 0.24-0.76). Among women, high weight gain was positively associated with ovarian cancer (HR 2.48; 95% CI 1.05-5.85). Conclusion: These findings indicate that recent weight change may influence the incidence of several types of cancer.