期刊
CALCIFIED TISSUE INTERNATIONAL
卷 95, 期 6, 页码 540-546出版社
SPRINGER
DOI: 10.1007/s00223-014-9919-7
关键词
Thalassemia major; Osteoporosis; Trabecular bone score
Due to the increasing survival of thalassemic patients, osteopathy is a mounting clinical problem. Low bone mass alone cannot account for the high fracture risk described; impaired bone quality has been speculated but so far it cannot be demonstrated noninvasively. We studied bone quality in thalassemia major using trabecular bone score (TBS), a novel texture measurement extracted from spine dual-energy X-ray absorptiometry (DXA), proposed in postmenopausal and secondary osteoporosis as an indirect index of microarchitecture. TBS was evaluated in 124 adult thalassemics (age range 19-56 years), followed-up with optimal transfusional and therapeutical regimens, and in 65 non-thalassemic patients (22-52 years) undergoing DXA for different bone diseases. TBS was lower in thalassemic patients (1.04 +/- A 0.12 [range 0.80-1.30]) versus controls (1.34 +/- A 0.11 [1.06-1.52]) (p < 0.001), and correlated with BMD. TBS and BMD values correlated with age, indicating that thalassemia negatively affects both bone quality and quantity, especially as the patient gets older. TBS was 1.02 +/- A 0.11 [0.80-1.28] in the osteoporotic thalassemic patients, 1.08 +/- A 0.12 [0.82-1.30] in the osteopenic ones and 1.15 +/- A 0.10 [0.96-1.26] in those with normal BMD. No gender differences were found (males: 1.02 +/- A 0.13 [0.80-1.30], females 1.05 +/- A 0.11 [0.80-1.30]), nor between patients with and without endocrine-metabolic disorders affecting bone metabolism. Our findings from a large population with thalassemia major show that TBS is a valuable tool to assess noninvasively bone quality, and it may be related to fragility fracture risk in thalassemic osteopathy.
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