期刊
CALCIFIED TISSUE INTERNATIONAL
卷 92, 期 2, 页码 128-139出版社
SPRINGER
DOI: 10.1007/s00223-012-9607-4
关键词
Vitamin D; Bone; Pregnancy; Birth outcome; Infant; 25-Hydroxyvitamin D
The function and requirement of vitamin D during pregnancy for both mother and fetus have remained a mystery. This fact was highlighted by The Cochrane Review in 2000, which reported a lack of randomized controlled trials (RCTs) with respect to vitamin D requirements during pregnancy. Unfortunately, during the past decade only a single RCT has been performed with respect to vitamin D requirements during pregnancy. In this review we will discuss vitamin D metabolism during pregnancy as well as the consequences of vitamin D deficiency on skeletal, nonskeletal, and birth outcomes using birth observational data and data from our recent RCT. New RCT data strongly support previous observational studies in that improving nutritional vitamin D status will improve birth outcomes. The new RCT data indicate that 4,000 IU/day vitamin D-3 during pregnancy will normalize vitamin D metabolism and improve birth outcomes including primary cesarean section and comorbidities of pregnancy with no risk of side effects.
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