4.4 Review

Notch Regulation of Bone Development and Remodeling and Related Skeletal Disorders

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Article Biochemistry & Molecular Biology

Reciprocal Regulation of Notch and Nuclear Factor of Activated T-cells (NFAT) c1 Transactivation in Osteoblasts

Stefano Zanotti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone Mass

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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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The cautionary tale of side effects of chronic Notch1 inhibition

Sandra W. Ryeom

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Genetics & Heredity

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

Michael A. Simpson et al.

NATURE GENETICS (2011)

Article Genetics & Heredity

Loss of CHSY1, a Secreted FRINGE Enzyme, Causes Syndromic Brachydactyly in Humans via Increased NOTCH Signaling

Jing Tian et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2010)

Article Biochemistry & Molecular Biology

Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis

Duncan B. Sparrow et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2010)

Review Immunology

Notch Signaling in the Immune System

Freddy Radtke et al.

IMMUNITY (2010)

Review Immunology

Transcriptional regulation of bone and joint remodeling by NFAT

Despina Sitara et al.

IMMUNOLOGICAL REVIEWS (2010)

Article Endocrinology & Metabolism

Osteosclerosis Owing to Notch Gain of Function Is Solely Rbpj-Dependent

Jianning Tao et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Review Biochemistry & Molecular Biology

Notch and the Skeleton

Stefano Zanotti et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Reprint Biochemistry & Molecular Biology

Mutation of the fucose-specific β1,3 N-acetylglucosaminyltransferase UNG results in abnormal formation of the spine (Reprinted)

Sally L. Dunwoodie

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Review Biochemistry & Molecular Biology

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

Raphael Kopan et al.

Review Cell Biology

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

Mark E. Fortini

DEVELOPMENTAL CELL (2009)

Article Biochemistry & Molecular Biology

Notch signaling contributes to the pathogenesis of human osteosarcomas

Feyza Engin et al.

HUMAN MOLECULAR GENETICS (2009)

Article Biochemistry & Molecular Biology

The Notch-Responsive Transcription Factor Hes-1 Attenuates Osteocalcin Promoter Activity in Osteoblastic Cells

Ying Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Article Multidisciplinary Sciences

Direct inhibition of the NOTCH transcription factor complex

Raymond E. Moellering et al.

NATURE (2009)

Article Multidisciplinary Sciences

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development

Timothy J. Mead et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Biochemistry & Molecular Biology

Mutation of the fucose-specific β1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine

Sally L. Dunwoodie

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Article Genetics & Heredity

Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome

Alberto S. Cornier et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2008)

Article Endocrinology & Metabolism

Notch inhibits osteoblast differentiation and causes osteopenia

Stefano Zanotti et al.

ENDOCRINOLOGY (2008)

Article Biochemistry & Molecular Biology

Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis

Duncan B. Sparrow et al.

HUMAN MOLECULAR GENETICS (2008)

Article Biochemistry & Molecular Biology

The association of Notch2 and NF-κB accelerates RANKL-induced osteoclastogenesis

Hidefumi Fukushima et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Dimorphic effects of Notch signaling in bone homeostasis

Feyza Engin et al.

NATURE MEDICINE (2008)

Article Biochemistry & Molecular Biology

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

Matthew J. Hilton et al.

NATURE MEDICINE (2008)

Review Biochemistry & Molecular Biology

The many facets of Notch ligands

B. D'Souza et al.

ONCOGENE (2008)

Review Biochemistry & Molecular Biology

Notch3: from subtle structural differences to functional diversity

D. Bellavia et al.

ONCOGENE (2008)

Article Biochemistry & Molecular Biology

NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells

Shuting Bai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Regulation of Notch signaling by glycosylation

Pamela Stanley

CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)

Review Medicine, General & Internal

Mechanisms of anabolic therapies for osteoporosis

Ernesto Canalis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Biochemistry & Molecular Biology

The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo

Marie Monet et al.

HUMAN MOLECULAR GENETICS (2007)

Article Pathology

Osteoclasts: What do they do and how do they do it?

Steven L. Teitelbaum

AMERICAN JOURNAL OF PATHOLOGY (2007)

Review Anatomy & Morphology

Abnormal vertebral segmentation and the notch signaling pathway in man

Peter D. Turnpenny et al.

DEVELOPMENTAL DYNAMICS (2007)

Article Genetics & Heredity

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

Ryan McDaniell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Endocrinology & Metabolism

HES1 cooperates with pRb to activate RUNX2-dependent transcription

Jong-Seo Lee et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2006)

Article Biochemistry & Molecular Biology

Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/β-catenin but not bone morphogenetic protein signaling

V Deregowski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Developmental Biology

Generation of new Notch2 mutant alleles

B McCright et al.

GENESIS (2006)

Article Genetics & Heredity

Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype

DB Sparrow et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Biochemistry & Molecular Biology

The vitamin D receptor, Runx2, and the notch signaling pathway cooperate in the transcriptional regulation of osteopontin

Q Shen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Genetics & Heredity

Mutated MESP2 causes spondylocostal dysostosis in humans

NV Whittock et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2004)

Article Biochemistry & Molecular Biology

Notch signaling and inherited disease syndromes

T Gridley

HUMAN MOLECULAR GENETICS (2003)

Review Cell Biology

HES and HERP families: Multiple effectors of the Notch signaling pathway

T Iso et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2003)

Article Cell Biology

Dynamic expression and essential functions of Hes7 in somite segmentation

Y Bessho et al.

GENES & DEVELOPMENT (2001)