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Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis
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Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss
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Loss of CHSY1, a Secreted FRINGE Enzyme, Causes Syndromic Brachydactyly in Humans via Increased NOTCH Signaling
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Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies
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Notch3 in Human Breast Cancer Cell Lines Regulates Osteoblast-Cancer Cell Interactions and Osteolytic Bone Metastasis
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Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone
Rishard Salie et al.
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RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
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EUROPEAN JOURNAL OF HUMAN GENETICS (2010)
Transcriptional regulation of bone and joint remodeling by NFAT
Despina Sitara et al.
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Osteosclerosis Owing to Notch Gain of Function Is Solely Rbpj-Dependent
Jianning Tao et al.
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Mutation of the fucose-specific β1,3 N-acetylglucosaminyltransferase UNG results in abnormal formation of the spine (Reprinted)
Sally L. Dunwoodie
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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
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CELL (2009)
Notch Signaling: The Core Pathway and Its Posttranslational Regulation
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Notch signaling contributes to the pathogenesis of human osteosarcomas
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The Notch-Responsive Transcription Factor Hes-1 Attenuates Osteocalcin Promoter Activity in Osteoblastic Cells
Ying Zhang et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2009)
Direct inhibition of the NOTCH transcription factor complex
Raymond E. Moellering et al.
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Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development
Timothy J. Mead et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mutation of the fucose-specific β1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine
Sally L. Dunwoodie
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Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome
Alberto S. Cornier et al.
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被撤回的出版物: Critical role of Notch signaling in osteosarcoma invasion and metastasis (Retracted article. See vol. 19, pg. 5256, 2013)
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Notch inhibits osteoblast differentiation and causes osteopenia
Stefano Zanotti et al.
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Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis
Duncan B. Sparrow et al.
HUMAN MOLECULAR GENETICS (2008)
The association of Notch2 and NF-κB accelerates RANKL-induced osteoclastogenesis
Hidefumi Fukushima et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Dimorphic effects of Notch signaling in bone homeostasis
Feyza Engin et al.
NATURE MEDICINE (2008)
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
Matthew J. Hilton et al.
NATURE MEDICINE (2008)
The many facets of Notch ligands
B. D'Souza et al.
ONCOGENE (2008)
Notch3: from subtle structural differences to functional diversity
D. Bellavia et al.
ONCOGENE (2008)
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells
Shuting Bai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Regulation of Notch signaling by glycosylation
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CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)
Mechanisms of anabolic therapies for osteoporosis
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NEW ENGLAND JOURNAL OF MEDICINE (2007)
The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo
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Osteoclasts: What do they do and how do they do it?
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Abnormal vertebral segmentation and the notch signaling pathway in man
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NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
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AMERICAN JOURNAL OF HUMAN GENETICS (2006)
HES1 cooperates with pRb to activate RUNX2-dependent transcription
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Recent insights into the role of Notch signaling in tumorigenesis
KG Leong et al.
BLOOD (2006)
Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/β-catenin but not bone morphogenetic protein signaling
V Deregowski et al.
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Generation of new Notch2 mutant alleles
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Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype
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The vitamin D receptor, Runx2, and the notch signaling pathway cooperate in the transcriptional regulation of osteopontin
Q Shen et al.
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Mutated MESP2 causes spondylocostal dysostosis in humans
NV Whittock et al.
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T Gridley
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Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells
T Yamada et al.
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Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
M Logan et al.
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Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage
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