期刊
DIABETOLOGIA
卷 51, 期 3, 页码 417-425出版社
SPRINGER
DOI: 10.1007/s00125-007-0904-9
关键词
brain structure; cognition; MRI; neuroimaging; type 1 diabetes; white matter hyperintensities
资金
- NCRR NIH HHS [RR 01032] Funding Source: Medline
- NIDDK NIH HHS [P30 DK36836] Funding Source: Medline
- PHS HHS [R01060754] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR001032] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK036836] Funding Source: NIH RePORTER
Aim/hypothesis Studies investigating the structure, neurophysiology and functional outcomes of white matter among type 1 diabetes patients have given conflicting results. Our aim was to investigate the relationship between type 1 diabetes and white matter hyperintensities. Method We assessed white matter integrity (using magnetic resonance imaging), depressive symptoms and neuropsychological function in 114 type 1 diabetes patients and 58 age-matched non-diabetic controls. Results Only Fazekas grade 1 and 2 white matter hyperintensities were found among 114 long-duration, relatively young diabetes patients; the severity of lesions did not differ substantially from 58 healthy controls. White matter hyperintensities were not associated with depressive history or with clinical characteristics of diabetes, including retinopathy, severe hypoglycaemia or glycaemia control. Conclusions/interpretation Our data do not support an association between diabetes characteristics and white matter hyperintensities among relatively young type 1 diabetes participants.
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