期刊
JOURNAL OF IMMUNOLOGY
卷 180, 期 1, 页码 454-463出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.180.1.454
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- NHLBI NIH HHS [R01 HL069409, HL69409, R01 HL069409-07] Funding Source: Medline
- NIAID NIH HHS [R01 AI072689-02, R01 AI050844, AI49823, AI072689, R01 AI068056, AI61511, AI50844, T32 AI049823, R01 AI061511-04, R01 AI072689, R01 AI061511, AI68056] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL069409] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI072689, T32AI049823, R01AI068056, R01AI050844, R01AI061511] Funding Source: NIH RePORTER
Immunity to heterosubtypic strains of influenza is thought to be mediated primarily by memory T cells, which recognize epitopes in conserved proteins. However, the involvement of B cells in this process is controversial. We show in this study that influenza-specific memory T cells are insufficient to protect mice against a lethal challenge with a virulent strain of influenza in the absence of B cells. B cells contribute to protection in multiple ways. First, although non-neutralizing Abs by themselves do not provide any protection to challenge infection, they do reduce weight loss, lower viral titers, and promote recovery of mice challenged with a virulent heterosubtypic virus in the presence of memory T cells. Non-neutralizing Abs also facilitate the expansion of responding memory CD8 T cells. Furthermore, in cooperation with memory T cells, naive B cells also promote recovery from infection with a virulent heterosubtypic virus by generating new neutralizing Abs. These data demonstrate that B cells use multiple mechanisms to promote resistance to heterosubtypic strains of influenza and suggest that vaccines that elicit both memory T cells and Abs to conserved epitopes of influenza may be an effective defense against a wide range of influenza serotypes.
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