Matriderm® versus Integra®: A comparative experimental study

Aim: To compare engraftment rates and vascularisation in a rat model using either Integra Artificial Skin (R) or Matriderm (R). Methods: Matriderm (R) and the dermal part of Integra (R) were compared in a two-step procedure including matrix implantation and subsequent epidermal grafting. Neonatal rat epidermis was used as coverage to test for rapid and complete take. Results: Efficiency and quality of vascularisation expressed by take rate of epidermis, and thickness of resulting neodermis, were identical for both matrices. Conclusion: This first comparison of Matriderm (R) with Integra (R) in a rat model revealed no major differences in engraftment rates or vascularisation. (C) 2008 Elsevier Ltd and ISBI. All rights reserved.