期刊
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
卷 19, 期 4, 页码 367-376出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1203475415573663
关键词
psoriasis; psoriatic arthritis; nails; onychopathy; nail changes
类别
资金
- Canadian Rheumatology Association Roche Summer Studentship
Background: Nail changes are common in psoriatic arthritis (PsA), with varying relationships existing between skin, nail, and joint disease. Objective: To further characterize relationships between nail changes, psoriasis, and joint involvement in PsA patients. Methods: One hundred eighty-eight PsA patients had skin, fingernail, and rheumatological assessments completed. Hand and fingernail photographs were taken and reviewed by a dermatologist. Results: Higher swollen joint counts were associated with distal interphalangeal (DIP)/periungual psoriasis (P = .001), more splinter hemorrhages (P = .006), and any nail bed change (P = .03). Higher tender joint counts were associated with rough onychorrhexis (P < .001), DIP/periungual psoriasis (P = .03), red lunula (P = .001), nail crumbling (P = .046), any nail matrix (P = .03), and nail bed change (P = .03). Joint involvement was associated with same-digit nail changes; strongest association was swollen or tender DIP with subungual hyperkeratosis, odds ratio = 26.6 (95% CI, 5.1-139.1). Conclusion: The DIP/periungual psoriasis and specific nail changes were associated with higher joint counts and certain nail changes with same-digit joint involvement.
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